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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279 Species: Rattus norvegicus RGD Object: Gene Symbol: Cat Name: catalase

Acc ID: CHEBI:35549 Term: perfluorooctanoic acid Definition: A fluoroalkanoic acid that has formula C8HF15O2. CasRN: 335-67-1 Chemical ID: MESH:C023036

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:732740	6480464	CTD	perfluorooctanoic acid results in increased activity of CAT protein	PMID:19468714
affects expression	ISO	RGD:737448	6480464	CTD	perfluorooctanoic acid affects the expression of CAT mRNA	PMID:19429403
increases activity	ISO	RGD:737448	6480464	CTD	perfluorooctanoic acid results in increased activity of CAT protein	PMID:8602878 PMID:1293309
affects activity	EXP		6480464	CTD	perfluorooctanoic acid affects the activity of CAT protein	PMID:14706239
decreases activity	EXP		6480464	CTD	perfluorooctanoic acid results in decreased activity of CAT protein	PMID:9212780 PMID:10528994
increases activity	EXP		6480464	CTD	perfluorooctanoic acid results in increased activity of CAT protein	PMID:8250967 PMID:8011682 PMID:14757943
increases activity	ISO	RGD:737448	6480464	CTD	perfluorooctanoic acid results in increased activity of CAT protein	PMID:1293309 PMID:8602878
increases activity	EXP		6480464	CTD	perfluorooctanoic acid results in increased activity of CAT protein	PMID:8011682 PMID:8250967 PMID:14757943
decreases activity	EXP		6480464	CTD	perfluorooctanoic acid results in decreased activity of CAT protein	PMID:10528994 PMID:9212780
increases activity	EXP		6480464	CTD	perfluorooctanoic acid results in increased activity of CAT protein	PMID:14757943 PMID:8011682 PMID:8250967
increases activity	EXP		6480464	CTD	perfluorooctanoic acid results in increased activity of CAT protein	PMID:8250967 PMID:14757943 PMID:8011682