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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases expressionEXP 6480464CTDFructose results in increased expression of CASP1 protein; Fructose results in increased expression of CASP1 protein modified formPMID:22426011 PMID:24491314
Casp1multiple interactionsEXP 6480464CTD[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein]; [Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Quercetin inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein]PMID:22426011 PMID:24491314 PMID:34939712
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