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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CASP1 mRNAPMID:33387578
Casp1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CASP1 mRNAPMID:19520675 PMID:34747641
Casp1affects expressionISOCasp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CASP1 mRNAPMID:26377647
Casp1decreases expressionISOCASP1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CASP1 mRNAPMID:19684285
Casp1increases expressionISOCasp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CASP1 mRNAPMID:12167310 PMID:15310856 PMID:15972635 PMID:21041162
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CASP1 mRNAPMID:11007951 PMID:19684285
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CASP1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP1 protein]PMID:12878042 PMID:17942748
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTDCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CASP1 mRNA]PMID:11007951
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