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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca1
Name: BRCA1, DNA repair associated
Acc ID: CHEBI:28428
Term: beta-hexachlorocyclohexane
Definition: The beta-isomer of hexachlorocyclohexane.
Chemical ID: MESH:C023888
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1increases expressionISOBRCA1 (Homo sapiens)6480464CTDbeta-hexachlorocyclohexane results in increased expression of BRCA1 mRNAPMID:20206645
Brca1multiple interactionsISOBRCA1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]PMID:20206645
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