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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca1
Name: BRCA1, DNA repair associated
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1increases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of BRCA1 mRNAPMID:23969067
Brca1affects response to substanceISOBRCA1 (Homo sapiens)6480464CTDBRCA1 protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracenePMID:21507987
Brca1increases expressionISOBrca1 (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of BRCA1 proteinPMID:25448685
Brca1multiple interactionsISOBrca1 (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [A gene mutant form results in decreased expression of BRCA1 protein]; A gene mutant form inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BRCA1 protein]PMID:25448685
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