GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Brca1 | increases response to substance | ISO | Brca1 (Mus musculus) | 6480464 | CTD | BRCA1 gene mutant form results in increased susceptibility to Ethanol | PMID:26629949 | Brca1 | multiple interactions | ISO | Brca1 (Mus musculus) | 6480464 | CTD | [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased phosphorylation of H2AX protein; BRCA1 gene mutant form promotes the reaction [Ethanol results in increased phosphorylation of H2AX protein] | PMID:26629949 | | ||||||||||||||||||||||
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