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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1affects expressionEXP 6480464CTDArsenic Trioxide affects the expression of BCL2L1 proteinPMID:23337567
Bcl2l1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of BCL2L1 mRNA; Arsenic Trioxide results in decreased expression of BCL2L1 proteinPMID:19730151 PMID:23201927 PMID:28391263
Bcl2l1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]]; salvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]; salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]PMID:23201927 PMID:28391263
Bcl2l1affects expressionISOBCL2L1 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of BCL2L1 proteinPMID:23770046
Bcl2l1affects response to substanceISOBCL2L1 (Homo sapiens)6480464CTDBCL2L1 protein affects the susceptibility to Arsenic TrioxidePMID:10648417 PMID:11468182
Bcl2l1decreases expressionISOBcl2l1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of BCL2L1 mRNA; Arsenic Trioxide results in decreased expression of BCL2L1 proteinPMID:28454374 PMID:28587418
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of BCL2L1 mRNA; Arsenic Trioxide results in decreased expression of BCL2L1 proteinPMID:11739184 PMID:12480548 PMID:15142122 PMID:15665116 PMID:16105982 PMID:16360329 PMID:18349030 PMID:18546268 PMID:19763917 PMID:21889928 PMID:23337567 PMID:23861973 PMID:24466103 PMID:24944602 PMID:24956101 PMID:25335113 PMID:25416439 PMID:27561292 PMID:29738779 PMID:30472098 PMID:34413873
Bcl2l1increases expressionISOBCL2L1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of BCL2L1 mRNA; Arsenic Trioxide results in increased expression of BCL2L1 proteinPMID:17530438 PMID:23082001
Bcl2l1multiple interactionsISOBcl2l1 (Mus musculus)6480464CTD[Genistein co-treated with Arsenic Trioxide] results in decreased expression of BCL2L1 protein; Arsenic Trioxide promotes the reaction [Drugs, Chinese Herbal results in decreased expression of BCL2L1 protein]; Drugs, Chinese Herbal promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]PMID:21078540 PMID:28587418
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with epigallocatechin gallate] results in decreased expression of BCL2L1 protein; [Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased expression of BCL2L1 protein; [Arsenic Trioxide co-treated with IL24 protein] results in decreased expression of BCL2L1; [Arsenic Trioxide co-treated with Quercetin] results in decreased expression of BCL2L1 protein; [BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of BCL2L1 mRNA; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of BCL2L1 protein; [paricalcitol co-treated with Arsenic Trioxide] results in decreased expression of BCL2L1; [Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; allicin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]; Genistein promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]; Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]; MAPK8 affects the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]]PMID:12883035 PMID:15142122 PMID:15781666 PMID:18281123 PMID:18359480 PMID:18546268 PMID:20950636 PMID:21078540 PMID:23082001 PMID:24956101 PMID:27561292 PMID:32645343
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