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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDPaclitaxel results in decreased expression of BCL2L1 mRNA; Paclitaxel results in decreased expression of BCL2L1 proteinPMID:11774260 PMID:14749477 PMID:18058816 PMID:23956100
Bcl2l1decreases response to substanceISOBCL2L1 (Homo sapiens)6480464CTDBCL2L1 protein results in decreased susceptibility to PaclitaxelPMID:11468182 PMID:16080463 PMID:16275990
Bcl2l1increases expressionISOBCL2L1 (Homo sapiens)6480464CTDPaclitaxel results in increased expression of BCL2L1 mRNA; Paclitaxel results in increased expression of BCL2L1 proteinPMID:10822281
Bcl2l1increases phosphorylationISOBCL2L1 (Homo sapiens)6480464CTDPaclitaxel results in increased phosphorylation of BCL2L1 proteinPMID:18521433
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTD[CXCL8 results in increased expression of BCL2L1 mRNA] which results in decreased susceptibility to Paclitaxel; [CXCL8 results in increased expression of BCL2L1 protein] which results in decreased susceptibility to Paclitaxel; [esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]PMID:16051289 PMID:16243823 PMID:21742513
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