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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of BCL2L1 proteinPMID:30506661
Bcl2l1increases expressionEXP 6480464CTDDexamethasone results in increased expression of BCL2L1 mRNA alternative form; Dexamethasone results in increased expression of BCL2L1 protein; Dexamethasone results in increased expression of BCL2L1 protein alternative formPMID:10200566 PMID:11319611 PMID:15388240 PMID:17635642 PMID:19339209
Bcl2l1multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]; Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Doxorubicin inhibits the reaction [Dexamethasone results in increased expression of BCL2L1 protein]; fludarabine inhibits the reaction [Dexamethasone results in decreased expression of BCL2L1 protein]; Mifepristone affects the reaction [Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of BCL2L1 protein]PMID:16407456 PMID:17635642 PMID:19339209 PMID:30506661
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of BCL2L1 proteinPMID:15804364 PMID:19428934
Bcl2l1increases expressionISOBcl2l1 (Mus musculus)6480464CTDDexamethasone results in increased expression of BCL2L1 mRNAPMID:22733784
Bcl2l1increases expressionISOBCL2L1 (Homo sapiens)6480464CTDDexamethasone results in increased expression of BCL2L1 mRNA alternative form; Dexamethasone results in increased expression of BCL2L1 protein alternative formPMID:11319611 PMID:17070682
Bcl2l1increases stabilityISOBCL2L1 (Homo sapiens)6480464CTDDexamethasone results in increased stability of BCL2L1 mRNAPMID:9326359
Bcl2l1multiple interactionsISOBcl2l1 (Mus musculus)6480464CTD2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [[Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of BCL2L1 protein]; [Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of BCL2L1 protein; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein]PMID:15987750 PMID:29704545
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [Cisplatin results in decreased expression of BCL2L1 mRNA]; Dexamethasone inhibits the reaction [Cisplatin results in decreased expression of BCL2L1 protein]; Dexamethasone inhibits the reaction [Cycloheximide results in increased expression of BCL2L1 protein]; Dexamethasone inhibits the reaction [Dactinomycin results in increased expression of BCL2L1 protein]; Dexamethasone inhibits the reaction [Dichlororibofuranosylbenzimidazole results in increased expression of BCL2L1 protein]PMID:21940343 PMID:9326359
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