RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2200
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Bcl2l1
Name:	Bcl2-like 1

Acc ID:	CHEBI:28748
Term:	doxorubicin
Definition:	An anthracycline antibiotic that has formula C27H29NO11.
CasRN:	23214-92-8
Chemical ID:	MESH:D004317

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in increased expression of BCL2L1 mRNA	PMID:15939500 PMID:18560228
increases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in increased expression of BCL2L1 protein	PMID:17912235
multiple interactions	ISO	RGD:735516	6480464	CTD	pluronic block copolymer p85 inhibits the reaction [Doxorubicin results in increased expression of BCL2L1 mRNA]	PMID:15939500
multiple interactions	ISO	RGD:735516	6480464	CTD	NFKB1 protein affects the reaction [Doxorubicin results in increased expression of BCL2L1 protein]	PMID:17912235
decreases response to substance	ISO	RGD:1552009	6480464	CTD	BCL2L1 protein results in decreased susceptibility to Doxorubicin	PMID:16439991
affects expression	ISO	RGD:1552009	6480464	CTD	Doxorubicin affects the expression of BCL2L1 mRNA	PMID:16439991
multiple interactions	ISO	RGD:1552009	6480464	CTD	Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]	PMID:17673183
multiple interactions	EXP		6480464	CTD	[Corticosterone results in increased expression of BCL2L1 protein] which results in decreased susceptibility to Doxorubicin	PMID:15755911
increases expression	ISO	RGD:1552009	6480464	CTD	Doxorubicin results in increased expression of BCL2L1 mRNA	PMID:15505089 PMID:15485691
decreases expression	ISO	RGD:1552009	6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:17673183
decreases expression	EXP		6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 mRNA	PMID:18400355
multiple interactions	EXP		6480464	CTD	Doxorubicin inhibits the reaction [Dexamethasone results in increased expression of BCL2L1 protein]	PMID:17635642
multiple interactions	EXP		6480464	CTD	GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA] TNF protein affects the reaction [GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]]	PMID:18400355
decreases expression	EXP		6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:18632596
decreases ubiquitination	EXP		6480464	CTD	Doxorubicin results in decreased ubiquitination of BCL2L1 protein	PMID:12967636
multiple interactions	EXP		6480464	CTD	Ginkgo biloba extract 761 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]	PMID:18632596
multiple interactions	ISO	RGD:735516	6480464	CTD	BCL2L1 protein inhibits the reaction [BID protein results in increased susceptibility to Doxorubicin]	PMID:15289866
multiple interactions	ISO	RGD:735516	6480464	CTD	BCL2L1 protein inhibits the reaction [sildenafil results in increased activity of Doxorubicin] sildenafil promotes the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]	PMID:20884855
affects response to substance	ISO	RGD:735516	6480464	CTD	BCL2L1 protein affects the susceptibility to Doxorubicin	PMID:17923112
decreases response to substance	ISO	RGD:735516	6480464	CTD	BCL2L1 protein results in decreased susceptibility to Doxorubicin	PMID:15781649 PMID:11468182
decreases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:17922852 PMID:20884855 PMID:16843435
multiple interactions	ISO	RGD:735516	6480464	CTD	[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA	PMID:15911101
multiple interactions	ISO	RGD:735516	6480464	CTD	Doxorubicin promotes the reaction [MAPK14 protein results in decreased expression of BCL2L1 protein]	PMID:16843435
decreases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 mRNA	PMID:19746155
decreases response to substance	ISO	RGD:735516	6480464	CTD	BCL2L1 protein results in decreased susceptibility to Doxorubicin	PMID:11468182 PMID:15781649
decreases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:16843435 PMID:20884855 PMID:17922852
increases expression	ISO	RGD:1552009	6480464	CTD	Doxorubicin results in increased expression of BCL2L1 mRNA	PMID:15485691 PMID:15505089
multiple interactions	ISO	RGD:735516	6480464	CTD	bisphenol A promotes the reaction [Doxorubicin results in increased expression of BCL2L1 protein]	PMID:19270784
increases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in increased expression of BCL2L1 protein	PMID:19270784 PMID:17912235
increases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in increased expression of BCL2L1 protein	PMID:17912235 PMID:19270784
increases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in increased expression of BCL2L1 mRNA	PMID:18560228 PMID:15939500
decreases expression	EXP		6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:14736733 PMID:18632596
decreases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:20884855 PMID:17922852 PMID:16843435
decreases expression	ISO	RGD:735516	6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:16843435 PMID:17922852 PMID:20884855
decreases expression	ISO	RGD:1552009	6480464	CTD	Doxorubicin results in decreased expression of BCL2L1 protein	PMID:17673183 PMID:20144634
multiple interactions	ISO	RGD:1552009	6480464	CTD	Silymarin inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]	PMID:20144634
multiple interactions	ISO	RGD:735516	6480464	CTD	[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]	PMID:19047049

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