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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]PMID:14505808
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of BCL2L1 mRNA; Quercetin results in decreased expression of BCL2L1 proteinPMID:16049707 PMID:16082193 PMID:16898267 PMID:18787224 PMID:23727915 PMID:24368982 PMID:24612139 PMID:25084985 PMID:25293876 PMID:25339540 PMID:30152185 PMID:30639267
Bcl2l1increases expressionISOBCL2L1 (Homo sapiens)6480464CTDQuercetin results in increased expression of BCL2L1 proteinPMID:14688022
Bcl2l1multiple interactionsISOBcl2l1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [4-nitro-3-cresol results in decreased expression of BCL2L1 protein]; Quercetin inhibits the reaction [4-nitrophenol results in decreased expression of BCL2L1 protein]; Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2L1 protein]; Quercetin inhibits the reaction [CPG-oligonucleotide results in increased expression of BCL2L1 protein]PMID:17046822 PMID:21337715 PMID:22467373 PMID:23997041
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTD[arsenic trioxide co-treated with Quercetin] results in decreased expression of BCL2L1 protein; [Cisplatin co-treated with Quercetin] results in decreased expression of BCL2L1 protein; [Quercetin results in increased susceptibility to Cisplatin] which results in decreased expression of BCL2L1 protein; Quercetin inhibits the reaction [BCL2L1 protein binds to BAX protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]; Quercetin promotes the reaction [BCL2L1 protein binds to BAD protein]PMID:16082193 PMID:16619537 PMID:18359480 PMID:18455702 PMID:27050144
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