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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2180
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp7b
Name: ATPase copper transporting beta
Acc ID: CHEBI:79997
Term: GW 4064
Definition: A stilbenoid that has formula C28H22Cl3NO4.
Chemical ID: MESH:C412815
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp7bmultiple interactionsISOAtp7b (Mus musculus)6480464CTDATP7B protein affects the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; ATP7B protein affects the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of ABCB11 mRNA]; GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of NR0B2 mRNA]PMID:26241054
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