GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Atp7b | increases response to substance | ISO | Atp7b (Mus musculus) | 6480464 | CTD | ATP7B gene mutant form results in increased susceptibility to Zinc Acetate | PMID:26241054 | Atp7b | multiple interactions | ISO | Atp7b (Mus musculus) | 6480464 | CTD | [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of ABCB11 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of RXRA mRNA | PMID:26241054 | |
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