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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2144
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp5
Name: aquaporin 5
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp5decreases expressionEXP 6480464CTDEstradiol results in decreased expression of AQP5 mRNAPMID:20381596 PMID:28341573
Aqp5increases expressionEXP 6480464CTDEstradiol results in increased expression of AQP5 mRNA; Estradiol results in increased expression of AQP5 proteinPMID:26372666 PMID:28341573
Aqp5multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of AQP5 mRNA; [Estradiol co-treated with Progesterone] results in increased expression of AQP5 protein; Progesterone inhibits the reaction [Estradiol results in decreased expression of AQP5 mRNA]; Progesterone promotes the reaction [Estradiol results in decreased expression of AQP5 protein]; Quercetin affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP5 mRNA]; Quercetin affects the reaction [Estradiol results in decreased expression of AQP5 mRNA]; Quercetin affects the reaction [Estradiol results in increased expression of AQP5 protein]PMID:28341573
Aqp5increases expressionISOAqp5 (Mus musculus)6480464CTDEstradiol results in increased expression of AQP5 mRNAPMID:19484750 PMID:19654927 PMID:24052564 PMID:32186404
Aqp5increases expressionISOAQP5 (Homo sapiens)6480464CTDEstradiol results in increased expression of AQP5 mRNAPMID:36828454
Aqp5multiple interactionsISOAqp5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of AQP5 mRNA]PMID:24052564
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