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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2100
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
Acc ID: CHEBI:17933
Term: calcidiol
Definition: A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.
Chemical ID: MESH:D002112
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alplincreases expressionISOALPL (Homo sapiens)6480464CTDCalcifediol results in increased expression of ALPL mRNA; Calcifediol results in increased expression of ALPL proteinPMID:21542014
Alplmultiple interactionsISOALPL (Homo sapiens)6480464CTDCYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL mRNA]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL protein]; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]PMID:21542014
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