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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5increases activityISOALOX5 (Homo sapiens)6480464CTDCalcitriol analog results in increased activity of ALOX5 proteinPMID:10799658
Alox5increases expressionISOALOX5 (Homo sapiens)6480464CTDCalcitriol results in increased expression of ALOX5 mRNAPMID:16002434 PMID:16129123 PMID:19244278
Alox5multiple interactionsISOALOX5 (Homo sapiens)6480464CTDBenzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of ALOX5 mRNA]PMID:19244278
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