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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5affects localizationEXP 6480464CTDHydrogen Peroxide affects the localization of ALOX5 proteinPMID:18951527
Alox5decreases activityEXP 6480464CTDHydrogen Peroxide results in decreased activity of ALOX5 proteinPMID:12388339
Alox5multiple interactionsEXP 6480464CTDbaicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]; Edaravone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]; Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein; SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]PMID:18951527 PMID:20139896
Alox5increases activityISOALOX5 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased activity of ALOX5 proteinPMID:10491155
Alox5multiple interactionsISOALOX5 (Homo sapiens)6480464CTD[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4; ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]; Masoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]; Resveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]PMID:10491155 PMID:10698703
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