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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of ALDH1A1 mRNAPMID:16221955 PMID:18692542 PMID:19162173 PMID:21723365
Aldh1a1increases expressionISOAldh1a1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of ALDH1A1 mRNAPMID:19429403 PMID:20936131
Aldh1a1increases expressionISOALDH1A1 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of ALDH1A1 mRNAPMID:21723365
Aldh1a1multiple interactionsISOAldh1a1 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ALDH1A1 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of ALDH1A1 mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of ALDH1A1 mRNAPMID:36331819
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