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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of ALDH1A1 mRNA; perfluorooctanoic acid results in increased expression of ALDH1A1 proteinPMID:16221955 PMID:19162173 PMID:21723365 PMID:34958885
Aldh1a1affects expressionISOAldh1a1 (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of ALDH1A1 mRNAPMID:18281256
Aldh1a1increases expressionISOAldh1a1 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of ALDH1A1 mRNAPMID:17681415 PMID:19429403
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