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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:17898
Term: all-trans-retinal
Definition: A retinal in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D012172
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1affects oxidationEXP 6480464CTDALDH1A1 protein affects the oxidation of RetinaldehydePMID:17167544
Aldh1a1multiple interactionsEXP 6480464CTDMagnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]; Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]PMID:17167544
Aldh1a1multiple interactionsISOALDH1A1 (Homo sapiens)6480464CTD[ALDH1A1 protein co-treated with NAD] results in increased oxidation of Retinaldehyde; ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde]; ALDH1A1 protein binds to and results in increased oxidation of RetinaldehydePMID:10559215 PMID:23220587
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