GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ahr | decreases expression | EXP | | 6480464 | CTD | Dexamethasone results in decreased expression of AHR protein | PMID:9804617 | Ahr | increases expression | EXP | | 6480464 | CTD | Dexamethasone results in increased expression of AHR mRNA | PMID:20035846 PMID:20832446 | Ahr | multiple interactions | EXP | | 6480464 | CTD | Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]] | PMID:17690134 | Ahr | affects binding | ISO | AHR (Homo sapiens) | 6480464 | CTD | Dexamethasone binds to AHR protein | PMID:10478797 | Ahr | affects localization | ISO | AHR (Homo sapiens) | 6480464 | CTD | Dexamethasone affects the localization of AHR protein | PMID:35405071 | Ahr | decreases expression | ISO | AHR (Homo sapiens) | 6480464 | CTD | Dexamethasone results in decreased expression of AHR mRNA; Dexamethasone results in decreased expression of AHR protein | PMID:17552871 PMID:19022236 | Ahr | increases degradation | ISO | AHR (Homo sapiens) | 6480464 | CTD | Dexamethasone results in increased degradation of AHR protein | PMID:24091107 | Ahr | increases expression | ISO | Ahr (Mus musculus) | 6480464 | CTD | Dexamethasone results in increased expression of AHR mRNA; Dexamethasone results in increased expression of AHR protein | PMID:18086832 | Ahr | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA; [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA]; Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein]]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of AHR mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA] | PMID:16054899 PMID:18086832 | Ahr | multiple interactions | ISO | AHR (Homo sapiens) | 6480464 | CTD | [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide co-treated with Dexamethasone] affects the localization of AHR protein; Dexamethasone inhibits the reaction [AHR protein results in increased expression of CYP1A1]; Dexamethasone inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]; Dexamethasone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; Dexamethasone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]; Dexamethasone promotes the reaction [IL1B protein affects the localization of AHR protein]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of AHR mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of AHR protein] | PMID:17552871 PMID:19022236 PMID:19356061 PMID:19463884 PMID:24091107 PMID:35405071 | | ||||||||||||||||||||||
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