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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:38728
Term: monocrotophos
Definition: An alkenyl phosphate that is the 4-(methylamino)-4-oxobut-2-en-2-yl ester of dimethyl phosphate.
Chemical ID: MESH:D008999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects expressionISOAHR (Homo sapiens)6480464CTDMonocrotophos affects the expression of AHR proteinPMID:22733800
Ahrincreases expressionISOAHR (Homo sapiens)6480464CTDMonocrotophos results in increased expression of AHR mRNAPMID:22733800
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTD[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR proteinPMID:22733800
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