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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects activityEXP 6480464CTDGenistein affects the activity of AHR proteinPMID:19286049
Ahrmultiple interactionsEXP 6480464CTD[Genistein co-treated with Methylcholanthrene] affects the activity of AHR protein; [Genistein co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR proteinPMID:19286049
Ahraffects activityISOAHR (Homo sapiens)6480464CTDGenistein affects the activity of AHR proteinPMID:19286049
Ahraffects bindingISOAHR (Homo sapiens)6480464CTDGenistein binds to AHR proteinPMID:20436506
Ahrincreases activityISOAhr (Mus musculus)6480464CTDGenistein results in increased activity of AHR proteinPMID:17869316
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTDGenistein binds to and results in increased activity of AHR proteinPMID:14644660
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTD[Genistein co-treated with Methylcholanthrene] affects the activity of AHR protein; [Genistein co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR protein; Genistein inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]PMID:19286049 PMID:20057149
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