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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:27418
Term: 1,4-naphthoquinone
Definition: The parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties.
Chemical ID: MESH:C035342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects localizationISOAHR (Homo sapiens)6480464CTD1,4-naphthoquinone affects the localization of AHR proteinPMID:27853106
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTD[2-benzoquinone co-treated with 1,4-naphthoquinone] affects the localization of AHR protein; AHR protein affects the reaction [1,4-naphthoquinone results in increased expression of CYP1A1 mRNA]PMID:26558468
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