GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ahr | affects expression | EXP | | 6480464 | CTD | Estradiol affects the expression of AHR mRNA; Estradiol affects the expression of AHR protein | PMID:24777823 PMID:32145629 | Ahr | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of AHR mRNA | PMID:16614383 PMID:21187122 PMID:22127542 | Ahr | multiple interactions | EXP | | 6480464 | CTD | 11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in decreased expression of AHR mRNA]; [Progesterone co-treated with Estradiol] affects the expression of AHR mRNA; [Progesterone co-treated with Estradiol] affects the expression of AHR protein; Estradiol affects the reaction [Cadmium Chloride affects the expression of AHR mRNA]; Estradiol inhibits the reaction [Cadmium Chloride results in increased expression of AHR protein] | PMID:22127542 PMID:24777823 | Ahr | affects binding | ISO | AHR (Homo sapiens) | 6480464 | CTD | Estradiol binds to AHR protein | PMID:20436506 | Ahr | increases expression | ISO | AHR (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of AHR mRNA; Estradiol results in increased expression of AHR protein | PMID:19619570 PMID:21185374 PMID:22728919 PMID:28618207 PMID:31646340 | Ahr | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | AHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of LTF mRNA]]; Estradiol inhibits the reaction [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] | PMID:10072167 PMID:11006360 | Ahr | multiple interactions | ISO | AHR (Homo sapiens) | 6480464 | CTD | [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]] inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]; [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]] inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]; [AHR protein binds to ESR1 protein] affects the reaction [Estradiol results in increased expression of BRCA1 mRNA]; [Estradiol co-treated with Resveratrol] inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of AHR mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of AHR mRNA; [Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]; AHR gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to TFF1 promoter]]]; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ARNT protein binds to TFF1 promoter]]]; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]; AHR gene mutant form promotes the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to TFF1 promoter]]; AHR gene mutant form promotes the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]]; AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TFF1 promoter]]; AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]]; AHR protein affects the reaction [Estradiol results in increased expression of BRCA1 mRNA]; AHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]]; AHR protein inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; AHR protein inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]; AHR protein inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; AHR protein inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; AHR protein inhibits the reaction [Estradiol results in increased expression of TSKU mRNA]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]]; ARNT gene mutant form inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to TFF1 promoter]]]; Estradiol inhibits the reaction [6-methyl-1,3,8-trichlorodibenzofuran results in increased activity of AHR protein]; Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]; Estradiol promotes the reaction [[ESR1 protein binds to AHR protein binds to NRIP1 protein] which binds to TFF1 promoter]; Estradiol promotes the reaction [[ESR1 protein binds to AHR protein binds to NRIP1 protein] which binds to TSKU promoter]; Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]; Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]; Estradiol promotes the reaction [AHR protein binds to HSPB8 promoter]; Estradiol promotes the reaction [AHR protein binds to TFF1 promoter]; Estradiol promotes the reaction [AHR protein binds to TSKU promoter]; Estradiol promotes the reaction [ESR1 protein binds to AHR protein binds to NRIP1 protein]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CAD promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TFF1 promoter]]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of AHR protein]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to CYP1B1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to GREB1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [AHR protein binds to TFF1 promoter]] | PMID:11165043 PMID:15026081 PMID:15207704 PMID:16489025 PMID:16675542 PMID:19619570 PMID:20631324 PMID:22071320 PMID:22235307 PMID:23524099 PMID:24299737 PMID:28618207 PMID:30165855 PMID:9166778 | | ||||||||||||||||||||||
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