GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ahr | increases response to substance | EXP | | 6480464 | CTD | AHR gene mutant form results in increased susceptibility to Lipopolysaccharides | PMID:27590929 | Ahr | increases expression | ISO | Ahr (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of AHR mRNA; Lipopolysaccharides results in increased expression of AHR protein | PMID:24302727 PMID:26259605 PMID:9547351 | Ahr | increases expression | ISO | AHR (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of AHR mRNA; Lipopolysaccharides results in increased expression of AHR protein | PMID:24302727 PMID:27783115 | Ahr | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | AHR gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of CYP1A1 mRNA]; AHR promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of CCL20 protein]; AHR promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]; AHR protein affects the reaction [[Dust co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Dust co-treated with Lipopolysaccharides] results in increased expression of IL22 mRNA]; AHR protein affects the reaction [[Dust co-treated with Lipopolysaccharides] results in increased expression of PTGS2 mRNA]; AHR protein affects the reaction [[Dust co-treated with Lipopolysaccharides] results in increased secretion of IL17A protein]; AHR protein affects the reaction [[Dust co-treated with Lipopolysaccharides] results in increased secretion of IL22 protein]; AHR protein affects the reaction [[Particulate Matter co-treated with Lipopolysaccharides] results in increased expression of AHRR mRNA]; AHR protein affects the reaction [[Particulate Matter co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Particulate Matter co-treated with Lipopolysaccharides] results in increased expression of IL17A mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of STAT5A mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CXCL1 protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IFNG protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; AHR protein affects the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of IL22 mRNA]; AHR protein affects the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of PTGS2 mRNA]; AHR protein affects the susceptibility to [[Lipopolysaccharides co-treated with indole-3-carbinol] results in increased secretion of IL10 protein]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of CXCL1 protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IFNG protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]]; IL10 protein inhibits the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]]; IL10 protein promotes the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein]]; Lipopolysaccharides promotes the reaction [AHR protein binds to CCL20 promoter]; Lipopolysaccharides promotes the reaction [AHR protein binds to CYP1A1 promoter]; Lipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IGH enhancer]]; RELA mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of AHR mRNA] | PMID:21948866 PMID:22273745 PMID:24302727 PMID:26259605 PMID:26377645 PMID:29689377 | Ahr | multiple interactions | ISO | AHR (Homo sapiens) | 6480464 | CTD | [Lipopolysaccharides co-treated with resveratrol] results in decreased expression of AHR mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; AHR protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of AHR mRNA]; RELA mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of AHR mRNA] | PMID:24302727 PMID:26667767 PMID:27783115 | | ||||||||||||||||||||||
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