GENE - CHEMICAL INTERACTIONS REPORT
RGD ID:
2071
Species:
Rattus norvegicus
RGD Object:
Gene
Symbol:
Agtr1b
Name:
angiotensin II receptor, type 1b
Acc ID:
CHEBI:6541
Term:
losartan
Definition:
A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
CasRN:
114798-26-4
Chemical ID:
MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
multiple interactions ISO RGD:68977 6480464 CTD Losartan binds to and results in decreased activity of AGTR1 protein PMID:10821809 PMID:15807884 decreases activity ISO RGD:68977 6480464 CTD Losartan results in decreased activity of AGTR1 protein PMID:9124547 multiple interactions ISO RGD:68977 6480464 CTD [Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone PMID:9124547 multiple interactions EXP 6480464 CTD [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA] PMID:15331931 multiple interactions EXP 6480464 CTD Losartan binds to and results in decreased activity of AGTR1 protein PMID:15809360 multiple interactions EXP 6480464 CTD Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein] PMID:15157388 increases expression EXP 6480464 CTD Losartan results in increased expression of AGTR1 mRNA PMID:9533614 multiple interactions ISO RGD:68977 6480464 CTD Losartan binds to and results in decreased activity of AGTR1 protein PMID:15807884 PMID:10821809 
