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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2070
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr1aincreases expressionISOAGTR1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of AGTR1 mRNA; Hydrogen Peroxide results in increased expression of AGTR1 proteinPMID:36162953
Agtr1aincreases expressionISOAgtr1a (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of AGTR1A mRNAPMID:22306536 PMID:30710622
Agtr1amultiple interactionsISOAGTR1 (Homo sapiens)6480464CTDepigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein]PMID:36162953
Agtr1amultiple interactionsISOAgtr1a (Mus musculus)6480464CTDAspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]PMID:22306536
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