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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtmultiple interactionsEXP 6480464CTDPPARG protein affects the reaction [Quercetin inhibits the reaction [AGT protein results in increased expression of FOS protein]]; PPARG protein affects the reaction [Quercetin inhibits the reaction [AGT protein results in increased expression of JUN protein]]; PPARG protein affects the reaction [Quercetin inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]]; PPARG protein affects the reaction [Quercetin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]]; Quercetin analog inhibits the reaction [AGT protein results in increased expression of BAX protein]; Quercetin analog inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Quercetin analog inhibits the reaction [AGT protein results in increased expression of NCF1 mRNA]; Quercetin inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; Quercetin inhibits the reaction [AGT protein results in increased expression of FOS protein]; Quercetin inhibits the reaction [AGT protein results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Quercetin inhibits the reaction [AGT protein results in increased expression of JUN protein]; Quercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; Quercetin inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]; Quercetin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]PMID:17059008 PMID:17374653 PMID:19794523 PMID:24039778 PMID:24117263
Agtdecreases expressionISOAGT (Homo sapiens)6480464CTDQuercetin results in decreased expression of AGT mRNAPMID:21632981
Agtmultiple interactionsISOAgt (Mus musculus)6480464CTD[Quercetin co-treated with Dietary Fats] results in decreased expression of AGT mRNAPMID:27260466
Agtmultiple interactionsISOAGT (Homo sapiens)6480464CTD[Quercetin co-treated with Catechin] inhibits the reaction [AGT protein affects the localization of NCF1 protein]PMID:22295890
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