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GENE - TERM ANNOTATION REPORT

RGD ID: 2068
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agrp
Name: agouti related neuropeptide
Acc ID: DOID:9970
Term: obesity
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Obesity "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agrp IEP 2311538RGDmRNA:increased expression:hypothalamus 
Agrp ISOAGRP (Homo sapiens)1300272RGD  
Agrp ISOAGRP (Homo sapiens)1625232RGDDNA:polymorphism:exon:c.199G>A, pAla67Thr (human) 
Agrp ISOAGRP (Homo sapiens)2314000RGDDNA:polymorphism:promoter:-38C>T (human) 
Agrp ISOAGRP (Homo sapiens)7240710OMIM  
Agrp ISOAGRP (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism 
Agrp ISOAGRP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity, late-onsetPMID:11602360 PMID:12213871 PMID:15054840 PMID:25741868
Agrp ISOAGRP (Homo sapiens)1331525GAD  
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