GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Afp | increases expression | EXP | | 152177911 | RGD | N-nitrosodiethylamine increases expression of Afp protein in serum in rats | | Afp | affects expression | EXP | | 6480464 | CTD | Diethylnitrosamine affects the expression of AFP mRNA | PMID:19822196 | Afp | increases expression | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased expression of AFP mRNA; Diethylnitrosamine results in increased expression of AFP protein; Diethylnitrosamine results in increased expression of AFP protein alternative form | PMID:11818250 PMID:19394651 PMID:19446540 PMID:24012840 PMID:24060683 PMID:24632418 PMID:24954034 PMID:27565560 PMID:29458170 PMID:29698782 PMID:30779474 PMID:32302048 PMID:35437842 | Afp | multiple interactions | EXP | | 6480464 | CTD | 1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP protein; brucine inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; citral inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; formylchromone analog inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; FR 118487 inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]; piperlongumine inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Rotenone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Silymarin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein alternative form]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] | PMID:19394651 PMID:19446540 PMID:24012840 PMID:24060683 PMID:24632418 PMID:24954034 PMID:28414157 PMID:28693887 PMID:28935427 PMID:29458170 PMID:29923357 PMID:30779474 PMID:32302048 PMID:35113675 PMID:35437842 | Afp | decreases expression | ISO | AFP (Homo sapiens) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of AFP mRNA | PMID:21527772 | Afp | increases expression | ISO | Afp (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of AFP mRNA; Diethylnitrosamine results in increased expression of AFP protein | PMID:15766596 PMID:24535843 PMID:29859236 | Afp | multiple interactions | ISO | Afp (Mus musculus) | 6480464 | CTD | [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; [Phenobarbital co-treated with Pregnenolone Carbonitrile co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; Diethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of AFP mRNA]; Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Sorafenib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] | PMID:21391223 PMID:23288052 PMID:24535843 PMID:29859236 PMID:33398415 | |
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