GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Adrb2 | multiple interactions | EXP | | 6480464 | CTD | [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein | PMID:16474418 | Adrb2 | decreases expression | ISO | ADRB2 (Homo sapiens) | 6480464 | CTD | Salmeterol Xinafoate results in decreased expression of ADRB2 protein | PMID:16980553 | Adrb2 | increases activity | ISO | ADRB2 (Homo sapiens) | 6480464 | CTD | Salmeterol Xinafoate results in increased activity of ADRB2 protein | PMID:34601065 | Adrb2 | increases phosphorylation | ISO | ADRB2 (Homo sapiens) | 6480464 | CTD | Salmeterol Xinafoate results in increased phosphorylation of ADRB2 protein | PMID:14722251 | Adrb2 | multiple interactions | ISO | Adrb2 (Mus musculus) | 6480464 | CTD | Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein | PMID:20061444 | Adrb2 | multiple interactions | ISO | ADRB2 (Homo sapiens) | 6480464 | CTD | [Salmeterol Xinafoate binds to ADRB2 protein] which results in increased expression of CFTR protein; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein; Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB2 protein] | PMID:10516654 PMID:12621035 PMID:14730417 PMID:16980553 | |
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