Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2060
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb2
Name: adrenoceptor beta 2
Acc ID: CHEBI:9012
Term: Salmeterol xinafoate
Definition: null
Chemical ID: MESH:D000068299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb2multiple interactionsEXP 6480464CTD[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Salmeterol Xinafoate binds to and results in increased activity of ADRB2 proteinPMID:16474418
Adrb2decreases expressionISOADRB2 (Homo sapiens)6480464CTDSalmeterol Xinafoate results in decreased expression of ADRB2 proteinPMID:16980553
Adrb2increases activityISOADRB2 (Homo sapiens)6480464CTDSalmeterol Xinafoate results in increased activity of ADRB2 proteinPMID:34601065
Adrb2increases phosphorylationISOADRB2 (Homo sapiens)6480464CTDSalmeterol Xinafoate results in increased phosphorylation of ADRB2 proteinPMID:14722251
Adrb2multiple interactionsISOAdrb2 (Mus musculus)6480464CTDSalmeterol Xinafoate binds to and results in increased activity of ADRB2 proteinPMID:20061444
Adrb2multiple interactionsISOADRB2 (Homo sapiens)6480464CTD[Salmeterol Xinafoate binds to ADRB2 protein] which results in increased expression of CFTR protein; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein; Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB2 protein]PMID:10516654 PMID:12621035 PMID:14730417 PMID:16980553
Go Back to source page   Continue to Ontology report