GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Adrb2 | affects binding | EXP | | 6480464 | CTD | Propranolol binds to ADRB2 protein | PMID:11483288 PMID:2462161 PMID:9593075 | Adrb2 | increases expression | EXP | | 6480464 | CTD | Propranolol results in increased expression of ADRB2 mRNA | PMID:20668454 | Adrb2 | multiple interactions | EXP | | 6480464 | CTD | Propranolol binds to and results in decreased activity of ADRB2 protein; Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Propranolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein] | PMID:11425575 PMID:2462161 PMID:2897299 | Adrb2 | affects binding | ISO | ADRB2 (Homo sapiens) | 6480464 | CTD | Propranolol binds to ADRB2 protein | PMID:10372227 PMID:2169833 | Adrb2 | decreases expression | ISO | ADRB2 (Homo sapiens) | 6480464 | CTD | Propranolol results in decreased expression of ADRB2 mRNA | PMID:15603589 | Adrb2 | multiple interactions | ISO | ADRB2 (Homo sapiens) | 6480464 | CTD | [Propranolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Propranolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Propranolol co-treated with ADRB2 protein] results in increased expression of GNAS protein; [Propranolol co-treated with ADRB2 protein] results in increased expression of GRK2 protein; Propranolol binds to and results in decreased activity of ADRB2 protein; Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein]; Propranolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [Norepinephrine binds to ADRB2 protein]; Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein] | PMID:10455254 PMID:10952688 PMID:12920204 PMID:14730417 PMID:17925438 PMID:24929186 PMID:6141285 | | ||||||||||||||||||||||
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