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GENE - TERM ANNOTATION REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: DOID:6000
Term: congestive heart failure
Definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Heart_disease "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb1 IMP 5129119RGD  
Adrb1 ISOADRB1 (Homo sapiens)737774RGDDNA:polymorphism: :p.R389G (human) 
Adrb1 ISOADRB1 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:7586371 PMID:12374873 PMID:14502278 PMID:15816327 PMID:21516734
Adrb1 ISOADRB1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Congestive heart failure and beta-blocker response, modifier ofPMID:10212248 PMID:12374873 PMID:16844790 PMID:17496726 PMID:25741868
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