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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2056
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra2a
Name: adrenoceptor alpha 2A
Acc ID: CHEBI:2665
Term: amitraz
Definition: A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.
Chemical ID: MESH:C014983
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra2amultiple interactionsEXP 6480464CTD[Idazoxan binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to amitraz; amitraz binds to and results in increased activity of ADRA2A proteinPMID:10582558
Adra2adecreases activityISOADRA2A (Homo sapiens)6480464CTDamitraz results in decreased activity of ADRA2A proteinPMID:21251949
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