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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adm
Name: adrenomedullin
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Admdecreases expressionEXP 6480464CTDPhenylephrine results in decreased expression of ADM mRNAPMID:11470465
Admdecreases response to substanceEXP 6480464CTDADM protein results in decreased susceptibility to PhenylephrinePMID:15370692
Admdecreases secretionEXP 6480464CTDPhenylephrine results in decreased secretion of ADM proteinPMID:11470465
Admincreases expressionEXP 6480464CTDPhenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM proteinPMID:17250927
Admmultiple interactionsEXP 6480464CTD[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]PMID:11470465 PMID:17250927
Admdecreases response to substanceISOADM (Homo sapiens)6480464CTDADM protein results in decreased susceptibility to PhenylephrinePMID:15370692
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