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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adm
Name: adrenomedullin
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Admincreases expressionEXP 6480464CTDOxygen deficiency results in increased expression of ADM mRNA; Oxygen deficiency results in increased expression of ADM proteinPMID:10666155
Admaffects expressionISOAdm (Mus musculus)6480464CTDOxygen deficiency affects the expression of ADM mRNAPMID:17193925
Admincreases expressionISOADM (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of ADM mRNA; Oxygen deficiency results in increased expression of ADM proteinPMID:11032871 PMID:11754965 PMID:17175027 PMID:17968679 PMID:20042640 PMID:22279137 PMID:22745725 PMID:24403227 PMID:26516004
Admmultiple interactionsISOADM (Homo sapiens)6480464CTD1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]; Cycloheximide promotes the reaction [Oxygen deficiency results in increased expression of ADM mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]; Oxygen deficiency inhibits the reaction [darinaparsin results in increased expression of ADM mRNA]; Polyphenols inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]; Propolis inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA]PMID:11032871 PMID:22279137 PMID:22535156 PMID:22745725 PMID:24403227
Admmultiple interactionsISOAdm (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ADM mRNAPMID:30529165
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