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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2032 Species: Rattus norvegicus RGD Object: Gene Symbol: Adam10 Name: ADAM metallopeptidase domain 10

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects localization	ISO	RGD:735847	6480464	CTD	Tretinoin affects the localization of ADAM10 protein	PMID:19476501
increases expression	ISO	RGD:735847	6480464	CTD	Tretinoin results in increased expression of ADAM10 mRNA	PMID:16279945 PMID:19476501 PMID:15972296
increases expression	ISO	RGD:735847	6480464	CTD	Tretinoin results in increased expression of ADAM10 protein	PMID:19476501 PMID:16279945
affects localization	ISO	RGD:735848	6480464	CTD	Tretinoin affects the localization of ADAM10 protein	PMID:19476501
increases expression	ISO	RGD:735848	6480464	CTD	Tretinoin results in increased expression of ADAM10 mRNA Tretinoin results in increased expression of ADAM10 protein	PMID:19476501
increases expression	ISO	RGD:735847	6480464	CTD	Tretinoin results in increased expression of ADAM10 mRNA	PMID:15972296 PMID:19476501 PMID:16279945
increases expression	ISO	RGD:735847	6480464	CTD	Tretinoin results in increased expression of ADAM10 protein	PMID:16279945 PMID:19476501
increases expression	ISO	RGD:735847	6480464	CTD	Tretinoin results in increased expression of ADAM10 mRNA	PMID:16279945 PMID:15972296 PMID:19476501
increases expression	ISO	RGD:735847	6480464	CTD	Tretinoin results in increased expression of ADAM10 mRNA	PMID:15972296 PMID:16279945 PMID:19476501