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GENE - TERM ANNOTATION REPORT

RGD ID: 2029
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acvrl1
Name: activin A receptor like type 1
Acc ID: DOID:6432
Term: pulmonary hypertension
Definition: A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Pulmonary_hypertension "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/19555858 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acvrl1 IEP 1601116RGDmRNA:increased expression:lung 
Acvrl1disease_progressionISOACVRL1 (Homo sapiens)5128837RGDDNA:mutations (human) 
Acvrl1susceptibilityISOACVRL1 (Homo sapiens)1601117RGDassociated with hereditary haemorrhagic telangiectasia;DNA:missense mutations 
Acvrl1 ISOACVRL1 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:26540443
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