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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2025
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta1
Name: actin, alpha 1, skeletal muscle
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta1increases expressionEXP 6480464CTDPhenylephrine results in increased expression of ACTA1 mRNAPMID:10642269 PMID:11230109 PMID:12435817 PMID:15652358 PMID:15795322 PMID:16513848 PMID:16517124 PMID:16556869 PMID:17592507 PMID:18701451 PMID:19540241
Acta1multiple interactionsEXP 6480464CTDMAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]PMID:11513749 PMID:15652358 PMID:16513848 PMID:16517124 PMID:17592507 PMID:19540241
Acta1increases expressionISOActa1 (Mus musculus)6480464CTDPhenylephrine results in increased expression of ACTA1 mRNAPMID:18502941
Acta1multiple interactionsISOActa1 (Mus musculus)6480464CTD[Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]PMID:10710348 PMID:11499749 PMID:15201137 PMID:18502941
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