GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Acta1 | increases expression | EXP | | 6480464 | CTD | Phenylephrine results in increased expression of ACTA1 mRNA | PMID:10642269 PMID:11230109 PMID:12435817 PMID:15652358 PMID:15795322 PMID:16513848 PMID:16517124 PMID:16556869 PMID:17592507 PMID:18701451 PMID:19540241 | Acta1 | multiple interactions | EXP | | 6480464 | CTD | MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA] | PMID:11513749 PMID:15652358 PMID:16513848 PMID:16517124 PMID:17592507 PMID:19540241 | Acta1 | increases expression | ISO | Acta1 (Mus musculus) | 6480464 | CTD | Phenylephrine results in increased expression of ACTA1 mRNA | PMID:18502941 | Acta1 | multiple interactions | ISO | Acta1 (Mus musculus) | 6480464 | CTD | [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA] | PMID:10710348 PMID:11499749 PMID:15201137 PMID:18502941 | |
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