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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2015
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl1decreases expressionEXP 6480464CTDEthanol results in decreased expression of ACSL1 mRNA; Ethanol results in decreased expression of ACSL1 proteinPMID:24146112 PMID:26115886
Acsl1increases expressionEXP 6480464CTDEthanol results in increased expression of ACSL1 mRNA; Ethanol results in increased expression of ACSL1 proteinPMID:15353170 PMID:23200777
Acsl1multiple interactionsEXP 6480464CTDdioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA]; Silymarin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA]PMID:24146112 PMID:26115886
Acsl1affects splicingISOAcsl1 (Mus musculus)6480464CTDEthanol affects the splicing of ACSL1 mRNAPMID:30319688
Acsl1decreases expressionISOAcsl1 (Mus musculus)6480464CTDEthanol results in decreased expression of ACSL1 mRNA; Ethanol results in decreased expression of ACSL1 proteinPMID:24146112 PMID:34995708
Acsl1multiple interactionsISOAcsl1 (Mus musculus)6480464CTD[Ethanol co-treated with Diethylhexyl Phthalate] results in increased expression of ACSL1 mRNA; [Zinc deficiency co-treated with Ethanol] results in increased expression of ACSL1 mRNA; dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]PMID:24146112 PMID:24155903 PMID:32325186
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