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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1624095
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c39
Name: cytochrome P450, family 2, subfamily c, polypeptide 39
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c39decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of CYP2C39 mRNAPMID:17950772 PMID:20813756 PMID:23811191
Cyp2c39increases expressionEXP 6480464CTDpirinixic acid results in increased expression of CYP2C39 mRNAPMID:15777286 PMID:20059764 PMID:20936131
Cyp2c39multiple interactionsEXP 6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYP2C39 mRNA; [pirinixic acid co-treated with PPARA] results in decreased expression of CYP2C39 mRNA; NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of CYP2C39 mRNA]; PPARA protein affects the reaction [pirinixic acid results in increased expression of CYP2C39 mRNA]; PPARA protein promotes the reaction [pirinixic acid results in increased expression of CYP2C39 mRNA]PMID:15777286 PMID:17950772 PMID:19710929 PMID:20059764 PMID:20813756
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