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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595950
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lpar6
Name: lysophosphatidic acid receptor 6
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lpar6decreases expressionISOLPAR6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of P2RY5 mRNAPMID:20106945 PMID:21632981
Lpar6increases expressionISOLPAR6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of LPAR6 mRNA; Benzo(a)pyrene results in increased expression of P2RY5 mRNAPMID:20064835 PMID:26238291 PMID:30453624 PMID:32234424
Lpar6increases expressionISOLpar6 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of LPAR6 mRNA; Benzo(a)pyrene results in increased expression of P2RY5 mRNAPMID:19770486 PMID:21715664
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