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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: RT1-Ba
Name: RT1 class II, locus Ba
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RT1-Badecreases expressionISOH2-Aa (Mus musculus)6480464CTDOzone results in decreased expression of H2-AA mRNAPMID:12763052
RT1-Bamultiple interactionsISOH2-Aa (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of H2-AA mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of H2-AA mRNA; [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] inhibits the reaction [Ozone results in increased expression of LTA mRNA]; [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] inhibits the reaction [Ozone results in increased expression of TNF mRNA]; [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] results in decreased susceptibility to OzonePMID:20032013 PMID:34911549
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