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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atm
Name: ATM serine/threonine kinase
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atmincreases phosphorylationISOATM (Homo sapiens)6480464CTDEtoposide results in increased phosphorylation of ATM proteinPMID:37451322
Atmmultiple interactionsISOAtm (Mus musculus)6480464CTDEtoposide results in increased phosphorylation of and results in increased activity of ATM proteinPMID:22242153
Atmmultiple interactionsISOATM (Homo sapiens)6480464CTDEtoposide results in increased phosphorylation of and affects the localization of ATM protein; pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein]PMID:26259609
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