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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atm
Name: ATM serine/threonine kinase
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atmdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of ATM mRNAPMID:19730151
Atmincreases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of ATM proteinPMID:23337567
Atmdecreases expressionISOATM (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of ATM mRNA; Arsenic Trioxide results in decreased expression of ATM protein modified formPMID:19763917 PMID:20471514 PMID:28318385
Atmdecreases phosphorylationISOATM (Homo sapiens)6480464CTDArsenic Trioxide results in decreased phosphorylation of ATM proteinPMID:31597699
Atmincreases expressionISOATM (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ATM mRNAPMID:29274334
Atmmultiple interactionsISOATM (Homo sapiens)6480464CTD[ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of ATM protein; Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of ATM mRNA]PMID:29274334 PMID:30012499
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