GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Atm | affects methylation | ISO | ATM (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of ATM promoter | PMID:27901495 | Atm | affects response to substance | ISO | ATM (Homo sapiens) | 6480464 | CTD | ATM protein affects the susceptibility to Benzo(a)pyrene | PMID:22382310 | Atm | decreases expression | ISO | Atm (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of ATM mRNA | PMID:19770486 | Atm | decreases expression | ISO | ATM (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of ATM mRNA | PMID:20064835 | Atm | increases expression | ISO | Atm (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ATM mRNA | PMID:20713471 PMID:22228805 | Atm | increases expression | ISO | ATM (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ATM mRNA; Benzo(a)pyrene results in increased expression of ATM protein | PMID:17879257 PMID:22266578 | Atm | increases methylation | ISO | Atm (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of ATM exon; Benzo(a)pyrene results in increased methylation of ATM intron | PMID:27901495 | Atm | multiple interactions | ISO | Atm (Mus musculus) | 6480464 | CTD | ATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]; ATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene] | PMID:20888899 | Atm | multiple interactions | ISO | ATM (Homo sapiens) | 6480464 | CTD | [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA; Benzo(a)pyrene results in increased phosphorylation of and affects the localization of ATM protein; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA]; PARG affects the reaction [Benzo(a)pyrene results in increased expression of ATM mRNA]; PARG affects the reaction [Benzo(a)pyrene results in increased expression of ATM protein] | PMID:21882252 PMID:22266578 PMID:28461126 | | ||||||||||||||||||||||
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