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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atm
Name: ATM serine/threonine kinase
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atmincreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of ATM mRNAPMID:28115068
Atmmultiple interactionsEXP 6480464CTDEthanol promotes the reaction [Diethylhexyl Phthalate results in increased expression of ATM mRNA]; PQQ Cofactor inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ATM mRNA]PMID:28115068
Atmdecreases expressionISOAtm (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of ATM mRNAPMID:29385306
Atmmultiple interactionsISOATM (Homo sapiens)6480464CTDDiethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]PMID:30720231
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