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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081 Species: Rattus norvegicus RGD Object: Gene Symbol: Mpo Name: myeloperoxidase

Acc ID: CHEBI:27385 Term: tetrachloromethane Definition: A chloromethane that has formula CCl4. CasRN: 56-23-5 Chemical ID: MESH:D002251

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	EXP		6480464	CTD	Carbon Tetrachloride results in increased activity of MPO protein	PMID:14697411 PMID:16278809 PMID:16724977
multiple interactions	EXP		6480464	CTD	[Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]	PMID:14697411
increases activity	EXP		6480464	CTD	Carbon Tetrachloride results in increased activity of MPO protein	PMID:16278809 PMID:16724977 PMID:14697411
increases activity	EXP		6480464	CTD	Carbon Tetrachloride results in increased activity of MPO protein	PMID:14697411 PMID:16724977 PMID:16278809
increases expression	EXP		6480464	CTD	Carbon Tetrachloride results in increased expression of MPO protein	PMID:15745444
multiple interactions	EXP		6480464	CTD	IGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of MPO protein]	PMID:15745444