GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tyr | decreases expression | ISO | TYR (Homo sapiens) | 6480464 | CTD | Colforsin results in decreased expression of TYR protein | PMID:28849034 | Tyr | increases activity | ISO | TYR (Homo sapiens) | 6480464 | CTD | Colforsin results in increased activity of TYR protein | PMID:17460731 | Tyr | increases expression | ISO | Tyr (Mus musculus) | 6480464 | CTD | Colforsin results in increased expression of TYR protein | PMID:28849034 | Tyr | increases expression | ISO | TYR (Homo sapiens) | 6480464 | CTD | Colforsin results in increased expression of TYR mRNA | PMID:23700242 PMID:28601556 | Tyr | multiple interactions | ISO | Tyr (Mus musculus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Colforsin results in increased expression of TYR protein]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TYR mRNA; [Colforsin co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TYR mRNA]; glabridin inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein] | PMID:28051915 PMID:28849034 | Tyr | multiple interactions | ISO | TYR (Homo sapiens) | 6480464 | CTD | [resveratrol co-treated with Colforsin] results in decreased activity of TYR protein; [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]; Colforsin results in increased expression of and results in increased activity of TYR protein; Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYR mRNA] | PMID:17460731 PMID:23700242 PMID:28601556 | | ||||||||||||||||||||||
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